Revolutionizing Gene Expression Monitoring with Kronos HT a luminometer for cyrcarian rythm

The ATTO Kronos HT system offers a breakthrough solution for real-time gene expression monitoring in living cells, providing scientists with an efficient and highly sensitive method to study gene transcription, biological rhythms, and drug responses. By utilizing bioluminescence of luciferase, this system enables high-throughput assays with precise monitoring over time, crucial for advancements in biological clock research, chronomedicine, and pharmacological studies.

A multi-well plate compatible model appeared in Kronos series which measures changes in gene expression over time with bioluminescence of luciferase while culturing cells.

Key Features of the ATTO Kronos HT System

1. High-Throughput Real-Time Monitoring

The Kronos HT system excels in measuring gene expression dynamically, making it ideal for:

  • Biological Clock Monitoring
  • Drug Response Analysis
  • Cytotoxicity Testing

2. Multiwell Plate Compatibility

Supports 24 and 96 well plates, optimizing throughput for up to 192 samples in a single run.

3. Non-Vibrating Cell Culture Mechanism

The Kronos HT scans without disturbing cell cultures, ensuring data integrity during long-term studies.

4. Multicolor Luciferase Assay

Supports multiple luciferase assays, allowing simultaneous analysis of gene activities in various pathways.

5. High-Sensitivity Detection

The cooled PMT detectors provide enhanced sensitivity by reducing thermal noise, enabling detection of weak signals.

6. Integrated Cell Culture Environment

Maintains optimal conditions for cells, including temperature, humidity, and CO2 concentration control.

Applications of ATTO Kronos HT in Research

  • Gene Expression and Transcriptional Activity

Track gene transcription dynamically for studies on dr ug response, promoter activity, and gene expression regulation.

  • Biological Clock and Chronomedicine

Monitor circadian rhythms and organ clocks, enabling progress in chronomedicine and treatment timing optimization.

  • Dr ug Development and Cytotoxicity Testing

Evaluate the effects of dr ug candidates over time, assessing activity inhibition and cytotoxicity.

  • Real-Time Data and User-Friendly Software

The Kronos HT system includes powerful software for real-time data monitoring, settings configuration, and easy data export.

Why Choose ATTO Kronos HT for Your Gene Expression Research ?

  • High throughput and efficiency
  • Advanced sensitivity
  • Cell integrity preservation
  • Multicolor flexibility